| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim71Protein Lin-41 HomologRing-Type E3 Ubiquitin Transferase Trim71Tripartite Motif-Containing Protein 71 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim71 antibodyAnti-Protein Lin-41 Homolog antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim71 antibodyAnti-Tripartite Motif-Containing Protein 71 antibodyAnti-TRIM71 antibodyAnti-LIN41 antibody |
Information sourced from Uniprot.org
