| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-TRIM71 (409-419) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TRIM71 |
| Gene ID: |
131405 |
| Uniprot ID: |
LIN41_HUMAN |
| Immunogen Region: |
409-419 |
| Accession Number: |
NP_001034200.1 |
| Immunogen Sequence: |
NKLESTISAVQ |
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim71Protein Lin-41 HomologRing-Type E3 Ubiquitin Transferase Trim71Tripartite Motif-Containing Protein 71 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim71 antibodyAnti-Protein Lin-41 Homolog antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim71 antibodyAnti-Tripartite Motif-Containing Protein 71 antibodyAnti-TRIM71 antibodyAnti-LIN41 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
