| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM62 |
| Gene ID: | 55223 |
| Uniprot ID: | TRI62_HUMAN |
| Immunogen Region: | 120-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human TRIM62 (NP_060677.2). |
| Immunogen Sequence: | HEQHQVTGIDDAFDELQREL KDQLQALQDSEREHTEALQL LKRQLAETKSSTKSLRTTIG EAFERLHRLLRERQKAMLEE LEADTARTLTDIEQKVQRYS QQLRKVQEGAQILQERLAET DRHTFLAGVASLSERLKGKI HETNLTYEDFPTSKYTGPLQ Y |
| Post Translational Modifications | Polyubiquitinated, autoubiquitinated in the presence of UBE2D2. |
| Function | E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors.leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim62Tripartite Motif-Containing Protein 62 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim62 antibodyAnti-Tripartite Motif-Containing Protein 62 antibodyAnti-TRIM62 antibody |
Information sourced from Uniprot.org