Anti-TRIM38 antibody (266-465) (STJ25968)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRIM38 (266-465) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM38 |
| Gene ID | 10475 |
| Uniprot ID | TRI38_HUMAN |
| Immunogen Region | 266-465 |
| Immunogen Sequence | VSLELHTMCNVSKLYFDVKK MLRSHQVSVTLDPDTAHHEL ILSEDRRQVTRGYTQENQDT SSRRFTAFPCVLGCEGFTSG RRYFEVDVGEGTGWDLGVCM ENVQRGTGMKQEPQSGFWTL RLCKKKGYVALTSPPTSLHL HEQPLLVGIFLDYEAGVVSF YNGNTGCHIFTFPKASFSDT LRPYFQVYQYSPLFLPPPGD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 266-465 of human TRIM38 (NP_006346.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim38Ring Finger Protein 15Tripartite Motif-Containing Protein 38Zinc Finger Protein Roret |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim38 antibodyAnti-Ring Finger Protein 15 antibodyAnti-Tripartite Motif-Containing Protein 38 antibodyAnti-Zinc Finger Protein Roret antibodyAnti-TRIM38 antibodyAnti-RNF15 antibodyAnti-RORET antibody |
Information sourced from Uniprot.org