| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim37Mulibrey Nanism ProteinRing-Type E3 Ubiquitin Transferase Trim37Tripartite Motif-Containing Protein 37 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | ChromosomeCytoplasmPerinuclear RegionPeroxisome MembranePeripheral Membrane ProteinFound In Vesicles Of The PeroxisomeAggregates As AggresomesA Perinuclear Region Where Certain Misfolded Or Aggregated Proteins Are Sequestered For Proteasomal Degradation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim37 antibodyAnti-Mulibrey Nanism Protein antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim37 antibodyAnti-Tripartite Motif-Containing Protein 37 antibodyAnti-TRIM37 antibodyAnti-KIAA0898 antibodyAnti-MUL antibodyAnti-POB1 antibody |
Information sourced from Uniprot.org
