| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tripartite motif-containing protein 3 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM3 |
| Gene ID: | 10612 |
| Uniprot ID: | TRIM3_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | TRIM3 Polyclonal Antibody detects endogenous levels of TRIM3 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TRIM3 at the amino acid range 1-50 |
| Function | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory. In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory. Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology. Positively regulates motility of microtubule-dependent motor protein KIF21B. Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3. In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. |
| Protein Name | Tripartite Motif-Containing Protein 3 Brain-Expressed Ring Finger Protein Ring Finger Protein 22 Ring Finger Protein 97 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm Early Endosome Golgi Apparatus Trans-Golgi Network Cell Projection Dendrite Mainly Located In The Golgi Apparatus And Transported To The Early Endosomes Upon Stimulation With Dsrna |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 3 antibody Anti-Brain-Expressed Ring Finger Protein antibody Anti-Ring Finger Protein 22 antibody Anti-Ring Finger Protein 97 antibody Anti-TRIM3 antibody Anti-BERP antibody Anti-RNF22 antibody Anti-RNF97 antibody |
Information sourced from Uniprot.org