| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tripartite motif-containing protein 29 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM29 |
| Gene ID: |
23650 |
| Uniprot ID: |
TRI29_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TRIM29 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human TRIM29 |
| Post Translational Modifications | Constitutively phosphorylated by PKC on serine/threonine in A431 cells. |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Protein Name | Tripartite Motif-Containing Protein 29Ataxia Telangiectasia Group D-Associated Protein |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmLysosomeColocalizes With Intermediate Filaments |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 29 antibodyAnti-Ataxia Telangiectasia Group D-Associated Protein antibodyAnti-TRIM29 antibodyAnti-ATDC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
