| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TRIM10 |
| Gene ID: |
10107 |
| Uniprot ID: |
TRI10_HUMAN |
| Immunogen Region: |
136-395 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 136-395 of human TRIM10 (NP_439893.2). |
| Immunogen Sequence: |
EDAAAPYREQIHKCLKCLRK EREEIQEIQSRENKRMQVLL TQVSTKRQQVISEFAHLRKF LEEQQSILLAQLESQDGDIL RQRDEFDLLVAGEICRFSAL IEELEEKNERPARELLTDIR STLIRCETRKCRKPVAVSPE LGQRIRDFPQQALPLQREMK MFLEKLCFELDYEPAHISLD PQTSHPKLLLSEDHQRAQFS YKWQNSPDNPQRFDRATCVL AHTGITGGRHTWVWMARVP |
| Function | E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling. In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1. |
| Protein Name | Tripartite Motif-Containing Protein 10B30-Ring Finger ProteinRing Finger Protein 9 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 10 antibodyAnti-B30-Ring Finger Protein antibodyAnti-Ring Finger Protein 9 antibodyAnti-TRIM10 antibodyAnti-RFB30 antibodyAnti-RNF9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
