Anti-TRAP1 antibody (445-704) (STJ25957)

Name: Anti-TRAP1 antibody (445-704) (STJ25957)
SKU: STJ25957
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25957

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Short Description	Rabbit polyclonal TRAP1 (445-704) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TRAP1
Gene ID	10131
Uniprot ID	TRAP1_HUMAN
Immunogen Region	445-704
Immunogen Sequence	GLFMREGIVTATEQEVKEDI AKLLRYESSALPSGQLTSLS EYASRMRAGTRNIYYLCAPN RHLAEHSPYYEAMKKKDTEV LFCFEQFDELTLLHLREFDK KKLISVETDIVVDHYKEEKF EDRSPAAECLSEKETEELMA WMRNVLGSRVTNVKVTLRLD THPAMVTVLEMGAARHFLRM QQLAKTQEERAQLLQPTLEI NPRHALIKKLNQLRASEPGL AQLLVDQIYENAMIAAGLV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 445-704 of human TRAP1 (NP_057376.2).

Tissue Specificity	Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Function	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Protein Name	Heat Shock Protein 75 Kda - Mitochondrial Hsp 75 Heat Shock Protein Family C Member 5 Tnfr-Associated Protein 1 Tumor Necrosis Factor Type 1 Receptor-Associated Protein Trap-1
Database Links	Reactome: R-HSA-611105 Reactome: R-HSA-71403
Cellular Localisation	Mitochondrion Mitochondrion Inner Membrane Mitochondrion Matrix
Alternative Antibody Names	Anti-Heat Shock Protein 75 Kda - Mitochondrial antibody Anti-Hsp 75 antibody Anti-Heat Shock Protein Family C Member 5 antibody Anti-Tnfr-Associated Protein 1 antibody Anti-Tumor Necrosis Factor Type 1 Receptor-Associated Protein antibody Anti-Trap-1 antibody Anti-TRAP1 antibody Anti-HSP75 antibody Anti-HSPC5 antibody

Information sourced from Uniprot.org