| Tissue Specificity | Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis. |
| Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10. Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination. |
| Protein Name | Transmembrane Protein 43Protein Luma |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneNucleus Inner MembraneMulti-Pass Membrane ProteinCell MembraneRetained In The Inner Nuclear Membrane Through Interaction With Emd And A- And B-LaminsThe N- And C-Termini Are Oriented Towards The NucleoplasmThe Majority Of The Hydrophilic Domain Resides In The Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Transmembrane Protein 43 antibodyAnti-Protein Luma antibodyAnti-TMEM43 antibodyAnti-UNQ2564 antibodyAnti-PRO6244 antibody |
Information sourced from Uniprot.org
