Anti-Transmembrane Protein 43 antibody [R07-9D4] (STJA0034935)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human TMEM43
General Information
| Short Description | Rabbit monoclonal anti-Transmembrane Protein 43 for use in WB and IHC-P in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-9D4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TMEM43 |
| Gene ID | 79188 |
| Uniprot ID | TMM43_HUMAN |
| Immunogen | A synthetic peptide of human TMEM43 |
Additional Info
| Tissue Specificity | Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis. |
| Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10. Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination. |
| Protein Name | Transmembrane Protein 43Protein Luma |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneNucleus Inner MembraneMulti-Pass Membrane ProteinCell MembraneRetained In The Inner Nuclear Membrane Through Interaction With Emd And A- And B-LaminsThe N- And C-Termini Are Oriented Towards The NucleoplasmThe Majority Of The Hydrophilic Domain Resides In The Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Transmembrane Protein 43 antibodyAnti-Protein Luma antibodyAnti-TMEM43 antibodyAnti-UNQ2564 antibodyAnti-PRO6244 antibody |
Information sourced from Uniprot.org