| Post Translational Modifications | O-glycosylated. Glycosylated by OGT.glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT. |
| Function | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. |
| Protein Name | Trafficking Kinesin-Binding Protein 1Protein Milton |
| Database Links | Reactome: R-MMU-9013419Reactome: -MMU-9013425 |
| Cellular Localisation | CytoplasmNucleusMitochondrionEarly EndosomeEndosomeMitochondrion MembraneCell CortexPredominantly Associated With Early EndosomeThe Localization To Early Endosomes Depends On Its Interaction With Hgs/HrsColocalizes With Mgarp At The Mitochondria |
| Alternative Antibody Names | Anti-Trafficking Kinesin-Binding Protein 1 antibodyAnti-Protein Milton antibodyAnti-Trak1 antibody |
Information sourced from Uniprot.org
