| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways. |
| Protein Name | E3 Ubiquitin Ligase Traf3ip2Adapter Protein CiksConnection To Ikk And Sapk/JnkE3 Ubiquitin-Protein Ligase CiksNuclear Factor Nf-Kappa-B Activator 1Act1Traf3-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Traf3ip2 antibodyAnti-Adapter Protein Ciks antibodyAnti-Connection To Ikk And Sapk/Jnk antibodyAnti-E3 Ubiquitin-Protein Ligase Ciks antibodyAnti-Nuclear Factor Nf-Kappa-B Activator 1 antibodyAnti-Act1 antibodyAnti-Traf3-Interacting Protein 2 antibodyAnti-TRAF3IP2 antibodyAnti-C6orf2 antibodyAnti-C6orf4 antibodyAnti-C6orf5 antibodyAnti-C6orf6 antibody |
Information sourced from Uniprot.org
