Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Goat polyclonal antibody anti-TRAF3IP2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 65kDa band observed in lysates of cell line MCF7 (calculated MW of 63.6kDa according to NP_679211.1). Recommended concentration: 1-3µg/ml. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | TRAF3IP2 |
Gene ID: | 10758 |
Uniprot ID: | CIKS_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_679211.1; NP_001157753.1 |
Specificity: | This antibody is expected to recognise reported isoforms 2 and 3 (NP_679211.1; NP_001157753.1). |
Immunogen Sequence: | PDTGHDSDKSDQ |
Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways. |
Protein Name | E3 Ubiquitin Ligase Traf3ip2Adapter Protein CiksConnection To Ikk And Sapk/JnkE3 Ubiquitin-Protein Ligase CiksNuclear Factor Nf-Kappa-B Activator 1Act1Traf3-Interacting Protein 2 |
Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Traf3ip2 antibodyAnti-Adapter Protein Ciks antibodyAnti-Connection To Ikk And Sapk/Jnk antibodyAnti-E3 Ubiquitin-Protein Ligase Ciks antibodyAnti-Nuclear Factor Nf-Kappa-B Activator 1 antibodyAnti-Act1 antibodyAnti-Traf3-Interacting Protein 2 antibodyAnti-TRAF3IP2 antibodyAnti-C6orf2 antibodyAnti-C6orf4 antibodyAnti-C6orf5 antibodyAnti-C6orf6 antibody |
Information sourced from Uniprot.org