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Anti-TRAF2 antibody (C-Term) (STJ70887)

STJ70887 (0. 1ug/ml) staining of HepG2 (A) cell lysate, (0. 5µg/ml) Human Ovary (B) lysate and (0. 1ug/ml) Jurkat (C) cell lysate. 35µg protein in RIPA buffer). Detected by chemiluminescence.
STJ70887 (0. 3ug/ml) staining of Mouse Testes lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
STJ70887 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing cytoplasmic and endoplasmic reticulum staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
STJ70887 Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing cytoplasmic and endoplasmic reticulum staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
STJ70886 Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line) , permeabilized with 0. 5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Anti-TRAF2 antibody (C-Term) (STJ70887)

SKU:

STJ70887-100

$409.73

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Goat
Applications:	Pep-ELISA/WB/IHC/IF/FC
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-TRAF2 (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-3.75µg/ml IF-Strong expression of the protein seen in the endoplasmic reticulums of HeLa and A431 cells. 10µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	TRAF2
Gene ID:	7186
Uniprot ID:	TRAF2_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_066961.2
Immunogen Sequence:	KMEAKNSYVRDD

Function	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation.this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Protein Name	Tnf Receptor-Associated Factor 2 E3 Ubiquitin-Protein Ligase Traf2 Ring-Type E3 Ubiquitin Transferase Traf2 Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5668541 Reactome: R-HSA-5675482 Reactome: R-HSA-5676594 Reactome: R-HSA-5689880 Reactome: R-HSA-69416 Reactome: R-HSA-75893 Reactome: R-HSA-933541 Reactome: R-HSA-933542 Reactome: R-HSA-9693928 Reactome: R-HSA-9758274
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Tnf Receptor-Associated Factor 2 antibody Anti-E3 Ubiquitin-Protein Ligase Traf2 antibody Anti-Ring-Type E3 Ubiquitin Transferase Traf2 antibody Anti-Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3 antibody Anti-TRAF2 antibody Anti-TRAP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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