| Post Translational Modifications | Phosphorylated in the RS domains. Dimethylation at Arg-241 is probably asymmetric. |
| Function | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. |
| Protein Name | Transformer-2 Protein Homolog BetaTra-2 BetaTra2-BetaHtra2-BetaSplicing Factor - Arginine/Serine-Rich 10Transformer-2 Protein Homolog B |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transformer-2 Protein Homolog Beta antibodyAnti-Tra-2 Beta antibodyAnti-Tra2-Beta antibodyAnti-Htra2-Beta antibodyAnti-Splicing Factor - Arginine/Serine-Rich 10 antibodyAnti-Transformer-2 Protein Homolog B antibodyAnti-TRA2B antibodyAnti-SFRS10 antibody |
Information sourced from Uniprot.org
