| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRA2B |
| Gene ID: |
6434 |
| Uniprot ID: |
TRA2B_HUMAN |
| Immunogen Region: |
1-100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRA2B (NP_004584.1). |
| Immunogen Sequence: |
MSDSGEQNYGERESRSASRS GSAHGSGKSARHTPARSRSK EDSRRSRSKSRSRSESRSRS RRSSRRHYTRSRSRSRSHRR SRSRSYSRDYRRRHSHSHSP |
| Tissue Specificity | Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. |
| Post Translational Modifications | Phosphorylated in the RS domains. Dimethylation at Arg-241 is probably asymmetric. |
| Function | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. |
| Protein Name | Transformer-2 Protein Homolog BetaTra-2 BetaTra2-BetaHtra2-BetaSplicing Factor - Arginine/Serine-Rich 10Transformer-2 Protein Homolog B |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transformer-2 Protein Homolog Beta antibodyAnti-Tra-2 Beta antibodyAnti-Tra2-Beta antibodyAnti-Htra2-Beta antibodyAnti-Splicing Factor - Arginine/Serine-Rich 10 antibodyAnti-Transformer-2 Protein Homolog B antibodyAnti-TRA2B antibodyAnti-SFRS10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
