• Western blot analysis of lysates from Mouse skin, using TPSAB1 Rabbit polyclonal antibody (STJ25946) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
  • Western blot analysis of lysates from Rat skin, using TPSAB1 Rabbit polyclonal antibody (STJ25946) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-TPSAB1 antibody (31-275) (STJ25946)

SKU:
STJ25946

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TPSAB1 (31-275) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TPSAB1
Gene ID: 7177
Uniprot ID: TRYB1_HUMAN
Immunogen Region: 31-275
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 31-275 of human TPSAB1 (NP_003285.2).
Immunogen Sequence: IVGGQEAPRSKWPWQVSLRV HGPYWMHFCGGSLIHPQWVL TAAHCVGPDVKDLAALRVQL REQHLYYQDQLLPVSRIIVH PQFYTAQIGADIALLELEEP VNVSSHVHTVTLPPASETFP PGMPCWVTGWGDVDNDERLP PPFPLKQVKVPIMENHICDA KYHLGAYTGDDVRIVRDDML CAGNTRRDSCQGDSGGPLVC KVNGTWLQAGVVSWGEGCAQ PNRPGIYTRVTYYLDWIHH
Tissue Specificity Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin.in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Protein Name Tryptase Alpha/Beta-1
Tryptase-1
Tryptase I
Tryptase Alpha-1
Database Links Reactome: R-HSA-1592389
Cellular Localisation Secreted
Released From The Secretory Granules Upon Mast Cell Activation
Alternative Antibody Names Anti-Tryptase Alpha/Beta-1 antibody
Anti-Tryptase-1 antibody
Anti-Tryptase I antibody
Anti-Tryptase Alpha-1 antibody
Anti-TPSAB1 antibody
Anti-TPS1 antibody
Anti-TPS2 antibody
Anti-TPSB1 antibody

Information sourced from Uniprot.org

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