| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-EKC/KEOPS complex subunit TPRKB (122-172 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPRKB |
| Gene ID: | 51002 |
| Uniprot ID: | TPRKB_HUMAN |
| Immunogen Region: | 122-172 aa |
| Specificity: | This antibody detects endogenous levels of TPRKB at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human TPRKB at the amino acid range 122-172 |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification. |
| Protein Name | Ekc/Keops Complex Subunit TprkbPrpk-Binding ProteinTp53rk-Binding Protein |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tprkb antibodyAnti-Prpk-Binding Protein antibodyAnti-Tp53rk-Binding Protein antibodyAnti-TPRKB antibodyAnti-CGI-121 antibodyAnti-My019 antibody |
Information sourced from Uniprot.org