Anti-TPP1 antibody (284-563) (STJ27594)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TPP1 (284-563) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPP1 |
| Gene ID | 1200 |
| Uniprot ID | TPP1_HUMAN |
| Immunogen Region | 284-563 |
| Immunogen Sequence | GANISTWVYSSPGRHEGQEP FLQWLMLLSNESALPHVHTV SYGDDEDSLSSAYIQRVNTE LMKAAARGLTLLFASGDSGA GCWSVSGRHQFRPTFPASSP YVTTVGGTSFQEPFLITNEI VDYISGGGFSNVFPRPSYQE EAVTKFLSSSPHLPPSSYFN ASGRAYPDVAALSDGYWVVS NRVPIPWVSGTSASTPVFGG ILSLINEHRILSGRPPLGFL NPRLYQQHGAGLFDVTRGC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 284-563 of human TPP1 (NP_000382.3). |
Additional Info
| Tissue Specificity | Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. |
| Post Translational Modifications | Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity. |
| Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. |
| Protein Name | Tripeptidyl-Peptidase 1Tpp-1Cell Growth-Inhibiting Gene 1 ProteinLysosomal Pepstatin-Insensitive ProteaseLpicTripeptidyl AminopeptidaseTripeptidyl-Peptidase ITpp-I |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | LysosomeMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Tripeptidyl-Peptidase 1 antibodyAnti-Tpp-1 antibodyAnti-Cell Growth-Inhibiting Gene 1 Protein antibodyAnti-Lysosomal Pepstatin-Insensitive Protease antibodyAnti-Lpic antibodyAnti-Tripeptidyl Aminopeptidase antibodyAnti-Tripeptidyl-Peptidase I antibodyAnti-Tpp-I antibodyAnti-TPP1 antibodyAnti-CLN2 antibodyAnti-GIG1 antibodyAnti-UNQ267 antibodyAnti-PRO304 antibody |
Information sourced from Uniprot.org