| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-TPO-R/CD110/c-Mpl (536-635) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S6MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MPL |
| Gene ID: |
4352 |
| Uniprot ID: |
TPOR_HUMAN |
| Immunogen Region: |
536-635 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 536-635 of human TPO-R/CD110/c-Mpl (P40238). |
| Immunogen Sequence: |
HRVLGQYLRDTAALSPPKAT VSDTCEEVEPSLLEILPKSS ERTPLPLCSSQAQMDYRRLQ PSCLGTMPLSVCPPMAESGS CCTTHIANHSYLPLSYWQQP |
| Tissue Specificity | Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. |
| Post Translational Modifications | Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination. |
| Function | Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. |
| Protein Name | Thrombopoietin ReceptorTpo-RMyeloproliferative Leukemia ProteinProto-Oncogene C-MplCd Antigen Cd110 |
| Database Links | Reactome: R-HSA-76009 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusCell Surface |
| Alternative Antibody Names | Anti-Thrombopoietin Receptor antibodyAnti-Tpo-R antibodyAnti-Myeloproliferative Leukemia Protein antibodyAnti-Proto-Oncogene C-Mpl antibodyAnti-Cd Antigen Cd110 antibodyAnti-MPL antibodyAnti-TPOR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
