| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPMT |
| Gene ID: | 7172 |
| Uniprot ID: | TPMT_HUMAN |
| Immunogen Region: | 1-245 |
| Immunogen Sequence: | MDGTRTSLDIEEYSDTEVQK NQVLTLEEWQDKWVNGKTAF HQEQGHQLLKKHLDTFLKGK SGLRVFFPLCGKAVEMKWFA DRGHSVVGVEISELGIQEFF TEQNLSYSEEPITEIPGTKV FKSSSGNISLYCCSIFDLPR TNIGKFDMIWDRGALVAINP GDRKCYADTMFSLLGKKFQY LLCVLSYDPTKHPGPPFYVP HAEIERLFGKICNIRCLEKV DAFEERHKSWGIDCLFEKL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1). |
| Function | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. |
| Protein Name | Thiopurine S-MethyltransferaseThiopurine Methyltransferase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-5578995Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thiopurine S-Methyltransferase antibodyAnti-Thiopurine Methyltransferase antibodyAnti-TPMT antibody |
Information sourced from Uniprot.org
