| Tissue Specificity | Present in primary breast cancer tissue, absent from normal breast tissue. |
| Post Translational Modifications | Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization. |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. |
| Protein Name | Tropomyosin Beta ChainBeta-TropomyosinTropomyosin-2 |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-445355 |
| Cellular Localisation | CytoplasmCytoskeletonAssociates With F-Actin Stress Fibers |
| Alternative Antibody Names | Anti-Tropomyosin Beta Chain antibodyAnti-Beta-Tropomyosin antibodyAnti-Tropomyosin-2 antibodyAnti-TPM2 antibodyAnti-TMSB antibody |
Information sourced from Uniprot.org
