Anti-TPK1 antibody (1-243) (STJ25939)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TPK1 (1-243) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPK1 |
| Gene ID | 27010 |
| Uniprot ID | TPK1_HUMAN |
| Immunogen Region | 1-243 |
| Immunogen Sequence | MEHAFTPLEPLLSTGNLKYC LVILNQPLDNYFRHLWNKAL LRACADGGANRLYDITEGER ESFLPEFINGDFDSIRPEVR EYYATKGCELISTPDQDHTD FTKCLKMLQKKIEEKDLKVD VIVTLGGLAGRFDQIMASVN TLFQATHITPFPIIIIQEES LIYLLQPGKHRLHVDTGMEG DWCGLIPVGQPCMQVTTTGL KWNLTNDVLAFGTLVSTSNT YDGSGVVTVETDHPLLWTM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-243 of human TPK1 (NP_071890.2). |
Additional Info
| Tissue Specificity | Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues. |
| Function | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence. |
| Protein Name | Thiamine Pyrophosphokinase 1Htpk1Placental Protein 20Pp20Thiamin Pyrophosphokinase 1 |
| Database Links | Reactome: R-HSA-196819 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Thiamine Pyrophosphokinase 1 antibodyAnti-Htpk1 antibodyAnti-Placental Protein 20 antibodyAnti-Pp20 antibodyAnti-Thiamin Pyrophosphokinase 1 antibodyAnti-TPK1 antibody |
Information sourced from Uniprot.org