Anti-TPH1 antibody (345-444) (STJ25936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TPH1 (345-444) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPH1 |
| Gene ID | 7166 |
| Uniprot ID | TPH1_HUMAN |
| Immunogen Region | 345-444 |
| Immunogen Sequence | LSGHAKVKPFDPKITCKQEC LITTFQDVYFVSESFEDAKE KMREFTKTIKRPFGVKYNPY TRSIQILKDTKSITSAMNEL QHDLDVVSDALAKVSRKPSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 345-444 of human TPH1 (NP_004170.1). |
Additional Info
| Tissue Specificity | Isoform 2: Seems to be less widely expressed than isoform 1. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. Phosphorylated.triggering degradation by the proteasome. |
| Function | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. |
| Protein Name | Tryptophan 5-Hydroxylase 1Tryptophan 5-Monooxygenase 1 |
| Database Links | Reactome: R-HSA-209931Reactome: R-HSA-9031628 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Tryptophan 5-Hydroxylase 1 antibodyAnti-Tryptophan 5-Monooxygenase 1 antibodyAnti-TPH1 antibodyAnti-TPH antibodyAnti-TPRH antibodyAnti-TRPH antibody |
Information sourced from Uniprot.org