| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPH1 |
| Gene ID: | 7166 |
| Uniprot ID: | TPH1_HUMAN |
| Immunogen Region: | 345-444 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-444 of human TPH1 (NP_004170.1). |
| Immunogen Sequence: | LSGHAKVKPFDPKITCKQEC LITTFQDVYFVSESFEDAKE KMREFTKTIKRPFGVKYNPY TRSIQILKDTKSITSAMNEL QHDLDVVSDALAKVSRKPSI |
| Tissue Specificity | Isoform 2: Seems to be less widely expressed than isoform 1. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. Phosphorylated.triggering degradation by the proteasome. |
| Function | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. |
| Protein Name | Tryptophan 5-Hydroxylase 1Tryptophan 5-Monooxygenase 1 |
| Database Links | Reactome: R-HSA-209931Reactome: R-HSA-9031628 |
| Alternative Antibody Names | Anti-Tryptophan 5-Hydroxylase 1 antibodyAnti-Tryptophan 5-Monooxygenase 1 antibodyAnti-TPH1 antibodyAnti-TPH antibodyAnti-TPRH antibodyAnti-TRPH antibody |
Information sourced from Uniprot.org