| Tissue Specificity | Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17. |
| Function | May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
| Protein Name | Tomoregulin-2Tr-2Hyperplastic Polyposis Protein 1Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains |
| Database Links | |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinIsoform 2: MembraneIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Tomoregulin-2 antibodyAnti-Tr-2 antibodyAnti-Hyperplastic Polyposis Protein 1 antibodyAnti-Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains antibodyAnti-TMEFF2 antibodyAnti-HPP1 antibodyAnti-TENB2 antibodyAnti-TPEF antibodyAnti-UNQ178 antibodyAnti-PRO204 antibody |
Information sourced from Uniprot.org
