| Post Translational Modifications | Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. |
| Function | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P). |
| Protein Name | Toll-Interacting Protein |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmEndosomeEarly EndosomeLocalized To Endo/Exosomal Vesicles |
| Alternative Antibody Names | Anti-Toll-Interacting Protein antibodyAnti-TOLLIP antibody |
Information sourced from Uniprot.org
