| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNR (1059-1358) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNR |
| Gene ID: |
7143 |
| Uniprot ID: |
TENR_HUMAN |
| Immunogen Region: |
1059-1358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1358 of human TNR (NP_003276.3). |
| Immunogen Sequence: |
ISWQPPRAEIENYVLTYKST DGSRKELIVDAEDTWIRLEG LLENTDYTVLLQAAQDTTWS SITSTAFTTGGRVFPHPQDC AQHLMNGDTLSGVYPIFLNG ELSQKLQVYCDMTTDGGGWI VFQRRQNGQTDFFRKWADYR VGFGNVEDEFWLGLDNIHRI TSQGRYELRVDMRDGQEAAF ASYDRFSVEDSRNLYKLRIG SYNGTAGDSLSYHQGRPFST EDRDNDVAVTNCAMSYKGA |
| Tissue Specificity | Brain specific. |
| Post Translational Modifications | Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure. O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan. |
| Function | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. |
| Protein Name | Tenascin-RTn-RJanusinRestrictin |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Tenascin-R antibodyAnti-Tn-R antibodyAnti-Janusin antibodyAnti-Restrictin antibodyAnti-TNR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
