Anti-TNPO1 antibody (790-890) (STJ111699)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TNPO1 (790-890) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNPO1 |
| Gene ID | 3842 |
| Uniprot ID | TNPO1_HUMAN |
| Immunogen Region | 790-890 |
| Immunogen Sequence | CPQEVAPMLQQFIRPWCTSL RNIRDNEEKDSAFRGICTMI SVNPSGVIQDFIFFCDAVAS WINPKDDLRDMFCKILHGFK NQVGDENWRRFSDQFPLPLK E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 790-890 of human TNPO1 (NP_002261.3). |
Additional Info
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates nuclear import of SRP19. Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner. Main mediator of PR-DUB complex component BAP1 nuclear import.acts redundantly with the karyopherins KPNA1 and KPNA2. (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. |
| Protein Name | Transportin-1Importin Beta-2Karyopherin Beta-2M9 Region Interaction ProteinMip |
| Database Links | Reactome: R-HSA-450513Reactome: R-HSA-5620924Reactome: R-HSA-9615933 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Transportin-1 antibodyAnti-Importin Beta-2 antibodyAnti-Karyopherin Beta-2 antibodyAnti-M9 Region Interaction Protein antibodyAnti-Mip antibodyAnti-TNPO1 antibodyAnti-KPNB2 antibodyAnti-MIP1 antibodyAnti-TRN antibody |
Information sourced from Uniprot.org