| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TNIK |
| Gene ID: |
23043 |
| Uniprot ID: |
TNIK_HUMAN |
| Immunogen Region: |
200-300 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TNIK (NP_055843.1). |
| Immunogen Sequence: |
IACDENPDATYDFKSDLWSL GITAIEMAEGAPPLCDMHPM RALFLIPRNPAPRLKSKKWS KKFQSFIESCLVKNHSQRPA TEQLMKHPFIRDQPNERQVR I |
| Tissue Specificity | Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. |
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. |
| Function | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Traf2 And Nck-Interacting Protein Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | NucleusCytoplasmRecycling EndosomeCytoskeletonAssociated With Recycling Endosomes And The Cytoskeletal Fraction Upon Rap2a Overexpression |
| Alternative Antibody Names | Anti-Traf2 And Nck-Interacting Protein Kinase antibodyAnti-TNIK antibodyAnti-KIAA0551 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
