| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tumor necrosis factor ligand superfamily member 12 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFSF12 |
| Gene ID: | 407977/8742 |
| Uniprot ID: | TNF12_HUMAN |
| Immunogen Region: | 41-90 aa |
| Specificity: | TWEAK Polyclonal Antibody detects endogenous levels of TWEAK protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TNFSF12 at the amino acid range 41-90 |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 12 Apo3 Ligand Tnf-Related Weak Inducer Of Apoptosis Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form |
| Database Links | Reactome: R-HSA-5668541 Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Tumor Necrosis Factor Ligand Superfamily Member 12 Secreted Form: Secreted Isoform Twe-Pril: Cell Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 12 antibody Anti-Apo3 Ligand antibody Anti-Tnf-Related Weak Inducer Of Apoptosis antibody Anti-Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form antibody Anti-TNFSF12 antibody Anti-APO3L antibody Anti-DR3LG antibody Anti-UNQ181 antibody Anti-PRO207 antibody |
Information sourced from Uniprot.org