| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tumor necrosis factor receptor superfamily member 21 (430-510 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF21 |
| Gene ID: | 27242 |
| Uniprot ID: | TNR21_HUMAN |
| Immunogen Region: | 430-510 aa |
| Specificity: | TNR21 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 430-510 |
| Post Translational Modifications | Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 21 Death Receptor 6 Cd Antigen Cd358 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Endocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros) |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 21 antibody Anti-Death Receptor 6 antibody Anti-Cd Antigen Cd358 antibody Anti-TNFRSF21 antibody Anti-DR6 antibody Anti-UNQ437 antibody Anti-PRO868 antibody |
Information sourced from Uniprot.org