Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TNFRSF1B (30-250) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TNFRSF1B |
Gene ID: | 7133 |
Uniprot ID: | TNR1B_HUMAN |
Immunogen Region: | 30-250 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_001057.1). |
Immunogen Sequence: | TPYAPEPGSTCRLREYYDQT AQMCCSKCSPGQHAKVFCTK TSDTVCDSCEDSTYTQLWNW VPECLSCGSRCSSDQVETQA CTREQNRICTCRPGWYCALS KQEGCRLCAPLRKCRPGFGV ARPGTETSDVVCKPCAPGTF SNTTSSTDICRPHQICNVVA IPGNASMDAVCTSTSPTRSM APGAVHLPQPVSTRSQHTQP TPEPSTAPSTSFLLPMGPSP P |
Post Translational Modifications | Phosphorylated.mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. |
Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1b Tumor Necrosis Factor Receptor 2 Tnf-R2 Tumor Necrosis Factor Receptor Type Ii Tnf-Rii Tnfr-Ii P75 P80 Tnf-Alpha Receptor Cd Antigen Cd120b Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 Tbp-2 Tbpii |
Database Links | Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 |
Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Tumor Necrosis Factor-Binding Protein 2: Secreted |
Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1b antibody Anti-Tumor Necrosis Factor Receptor 2 antibody Anti-Tnf-R2 antibody Anti-Tumor Necrosis Factor Receptor Type Ii antibody Anti-Tnf-Rii antibody Anti-Tnfr-Ii antibody Anti-P75 antibody Anti-P80 Tnf-Alpha Receptor antibody Anti-Cd Antigen Cd120b antibody Anti-Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 antibody Anti-Tbp-2 antibody Anti-Tbpii antibody Anti-TNFRSF1B antibody Anti-TNFBR antibody Anti-TNFR2 antibody |
Information sourced from Uniprot.org