• Immunofluorescence analysis of U2OS cells using TNFR2/TNFRSF1B Rabbit polyclonal antibody (STJ114881). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-TNFRSF1B antibody (30-250) (STJ114881)

SKU:
STJ114881

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Host: Rabbit
Applications: WB/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TNFRSF1B (30-250) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNFRSF1B
Gene ID: 7133
Uniprot ID: TNR1B_HUMAN
Immunogen Region: 30-250
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_001057.1).
Immunogen Sequence: TPYAPEPGSTCRLREYYDQT AQMCCSKCSPGQHAKVFCTK TSDTVCDSCEDSTYTQLWNW VPECLSCGSRCSSDQVETQA CTREQNRICTCRPGWYCALS KQEGCRLCAPLRKCRPGFGV ARPGTETSDVVCKPCAPGTF SNTTSSTDICRPHQICNVVA IPGNASMDAVCTSTSPTRSM APGAVHLPQPVSTRSQHTQP TPEPSTAPSTSFLLPMGPSP P
Post Translational Modifications Phosphorylated.mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1b
Tumor Necrosis Factor Receptor 2
Tnf-R2
Tumor Necrosis Factor Receptor Type Ii
Tnf-Rii
Tnfr-Ii
P75
P80 Tnf-Alpha Receptor
Cd Antigen Cd120b
Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2
Tbp-2
Tbpii
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Tumor Necrosis Factor-Binding Protein 2: Secreted
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 1b antibody
Anti-Tumor Necrosis Factor Receptor 2 antibody
Anti-Tnf-R2 antibody
Anti-Tumor Necrosis Factor Receptor Type Ii antibody
Anti-Tnf-Rii antibody
Anti-Tnfr-Ii antibody
Anti-P75 antibody
Anti-P80 Tnf-Alpha Receptor antibody
Anti-Cd Antigen Cd120b antibody
Anti-Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 antibody
Anti-Tbp-2 antibody
Anti-Tbpii antibody
Anti-TNFRSF1B antibody
Anti-TNFBR antibody
Anti-TNFR2 antibody

Information sourced from Uniprot.org