| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF18 |
| Gene ID: | 8784 |
| Uniprot ID: | TNR18_HUMAN |
| Immunogen Region: | 26-255 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-255 of human GITR/TNFRSF18 (NP_683699.1). |
| Immunogen Sequence: | QRPTGGPGCGPGRLLLGTGT DARCCRVHTTRCCRDYPGEE CCSEWDCMCVQPEFHCGDPC CTTCRHHPCPPGQGVQSQGK FSFGFQCIDCASGTFSGGHE GHCKPWTDCCWRCRRRPKTP EAASSPRKSGASDRQRRRGG WETCGCEPGRPPGPPTAASP SPGAPQAAGALRSALGRALL PWQQKWVQEGGSDQRPGPCS SAAAAGPCRRERETQSWPPS SLAGPDGVGS |
| Tissue Specificity | Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 18Activation-Inducible Tnfr Family ReceptorGlucocorticoid-Induced Tnfr-Related ProteinCd Antigen Cd357 |
| Database Links | Reactome: R-HSA-5669034Reactome: R-HSA-8877330 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 18 antibodyAnti-Activation-Inducible Tnfr Family Receptor antibodyAnti-Glucocorticoid-Induced Tnfr-Related Protein antibodyAnti-Cd Antigen Cd357 antibodyAnti-TNFRSF18 antibodyAnti-AITR antibodyAnti-GITR antibodyAnti-UNQ319 antibodyAnti-PRO364 antibody |
Information sourced from Uniprot.org