| Short Description : | Rabbit polyclonal TNFRSF12A (28-129) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF12A |
| Gene ID: | 51330 |
| Uniprot ID: | TNR12_HUMAN |
| Immunogen Region: | 28-129 |
| Immunogen Sequence: | EQAPGTAPCSRGSSWSADLD KCMDCASCRARPHSDFCLGC AAAPPAPFRLLWPILGGALS LTFVLGLLSGFLVWRRCRRR EKFTTPIEETGGEGCPAVAL IQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-129 of human TWEAKR/Fn14/CD266 (NP_057723.1). |
| Tissue Specificity | Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. |
| Function | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 12aFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14Fgf-Inducible 14Tweak-ReceptorTweakrCd Antigen Cd266 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 12a antibodyAnti-Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 antibodyAnti-Fgf-Inducible 14 antibodyAnti-Tweak-Receptor antibodyAnti-Tweakr antibodyAnti-Cd Antigen Cd266 antibodyAnti-TNFRSF12A antibodyAnti-FN14 antibody |
Information sourced from Uniprot.org
