Post Translational Modifications | Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. |
Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. |
Protein Name | Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2Hbacurd2Btb/Poz Domain-Containing Protein Tnfaip1Protein B12Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial |
Database Links | Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
Cellular Localisation | CytoplasmNucleusEndosomeColocalizes With Rhob In Endosomes |
Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2 antibodyAnti-Hbacurd2 antibodyAnti-Btb/Poz Domain-Containing Protein Tnfaip1 antibodyAnti-Protein B12 antibodyAnti-Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial antibodyAnti-TNFAIP1 antibodyAnti-BACURD2 antibodyAnti-EDP1 antibody |
Information sourced from Uniprot.org