Anti-TNFAIP1 antibody (71-120 aa) (STJ96049)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TNAP1 at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (71-120 aa) for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFAIP1 |
| Gene ID | 7126 |
| Uniprot ID | BACD2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TNAP1 at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | TNF-IP 1 Polyclonal Antibody detects endogenous levels of TNF-IP 1 protein. |
Additional Info
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. |
| Protein Name | Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2Hbacurd2Btb/Poz Domain-Containing Protein Tnfaip1Protein B12Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial |
| Database Links | Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmNucleusEndosomeColocalizes With Rhob In Endosomes |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2 antibodyAnti-Hbacurd2 antibodyAnti-Btb/Poz Domain-Containing Protein Tnfaip1 antibodyAnti-Protein B12 antibodyAnti-Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial antibodyAnti-TNFAIP1 antibodyAnti-BACURD2 antibodyAnti-EDP1 antibody |
Information sourced from Uniprot.org