Anti-TNF alpha antibody (100-150) {FITC} (STJ506269)

SKU:
STJ506269-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TNF alpha (100-150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 Mu g/Mu l
Dilution Range: ELISA 1:10, 000
ICC 1:50-1:100
IF 1:50-1:100
IHC 1:50-1:100
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TNF
Gene ID: 7124
Uniprot ID: TNFA_HUMAN
Immunogen Region: 100-150
Immunogen: Synthetic peptide corresponding to amino acids within region 100-150 on human Tumor necrosis factor alpha protein.
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. Promotes osteoclastogenesis and therefore mediates bone resorption. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Protein Name Tumor Necrosis Factor
Cachectin
Tnf-Alpha
Tumor Necrosis Factor Ligand Superfamily Member 2
Tnf-A Cleaved Into - Tumor Necrosis Factor - Membrane Form
N-Terminal Fragment
Ntf - Intracellular Domain 1
Icd1 - Intracellular Domain 2
Icd2 - C-Domain 1 - C-Domain 2 - Tumor Necrosis Factor - Soluble Form
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5626978
Reactome: R-HSA-5668541
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-75893
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor
Membrane Form: Membrane
Soluble Form: Secreted
C-Domain 1: Secreted
C-Domain 2: Secreted
Alternative Antibody Names Anti-Tumor Necrosis Factor antibody
Anti-Cachectin antibody
Anti-Tnf-Alpha antibody
Anti-Tumor Necrosis Factor Ligand Superfamily Member 2 antibody
Anti-Tnf-A Cleaved Into - Tumor Necrosis Factor - Membrane Form antibody
Anti-N-Terminal Fragment antibody
Anti-Ntf - Intracellular Domain 1 antibody
Anti-Icd1 - Intracellular Domain 2 antibody
Anti-Icd2 - C-Domain 1 - C-Domain 2 - Tumor Necrosis Factor - Soluble Form antibody
Anti-TNF antibody
Anti-TNFA antibody
Anti-TNFSF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance