| Post Translational Modifications | Palmitoylated.palmitoylation is required for localization to mitochondria-associated endoplasmic reticulum membrane (MAM). |
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux. |
| Protein Name | Thioredoxin-Related Transmembrane Protein 1Protein Disulfide-Isomerase Tmx1Thioredoxin Domain-Containing Protein 1Transmembrane Trx-Related Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinMitochondrion MembraneSecretedPredominantly Found In The Endoplasmic ReticulumSecreted In The Extracellular Space Following Thrombin StimulationLocalizes To Mitochondria-Associated Endoplasmic Reticulum Membrane (Mam)Palmitoylation Is Required For Mam Localization |
| Alternative Antibody Names | Anti-Thioredoxin-Related Transmembrane Protein 1 antibodyAnti-Protein Disulfide-Isomerase Tmx1 antibodyAnti-Thioredoxin Domain-Containing Protein 1 antibodyAnti-Transmembrane Trx-Related Protein antibodyAnti-TMX1 antibodyAnti-TMX antibodyAnti-TXNDC antibodyAnti-TXNDC1 antibodyAnti-PSEC0085 antibodyAnti-UNQ235 antibodyAnti-PRO268 antibody |
Information sourced from Uniprot.org
