| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMX1 |
| Gene ID: |
81542 |
| Uniprot ID: |
TMX1_HUMAN |
| Immunogen Region: |
210-280 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3). |
| Immunogen Sequence: |
KRRRPQPYPYPSKKLLSESA QPLKKVEEEQEADEEDVSEE EAESKEGTNKDFPQNAIRQR SLGPSLATDKS |
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, liver, placenta and lung. |
| Post Translational Modifications | Palmitoylated.palmitoylation is required for localization to mitochondria-associated endoplasmic reticulum membrane (MAM). |
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux. |
| Protein Name | Thioredoxin-Related Transmembrane Protein 1Protein Disulfide-Isomerase Tmx1Thioredoxin Domain-Containing Protein 1Transmembrane Trx-Related Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinMitochondrion MembraneSecretedPredominantly Found In The Endoplasmic ReticulumSecreted In The Extracellular Space Following Thrombin StimulationLocalizes To Mitochondria-Associated Endoplasmic Reticulum Membrane (Mam)Palmitoylation Is Required For Mam Localization |
| Alternative Antibody Names | Anti-Thioredoxin-Related Transmembrane Protein 1 antibodyAnti-Protein Disulfide-Isomerase Tmx1 antibodyAnti-Thioredoxin Domain-Containing Protein 1 antibodyAnti-Transmembrane Trx-Related Protein antibodyAnti-TMX1 antibodyAnti-TMX antibodyAnti-TXNDC antibodyAnti-TXNDC1 antibodyAnti-PSEC0085 antibodyAnti-UNQ235 antibodyAnti-PRO268 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
