| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMPRSS6 |
| Gene ID: | 164656 |
| Uniprot ID: | TMPS6_HUMAN |
| Immunogen Region: | 77-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-220 of human TMPRSS6 (NP_705837.1). |
| Immunogen Sequence: | GYKAEVMVSQVYSGSLRVLN RHFSQDLTRRESSAFRSETA KAQKMLKELITSTRLGTYYN SSSVYSFGEGPLTCFFWFIL QIPEHRRLMLSPEVVQALLV EELLSTVNSSAAVPYRAEYE VDPEGLVILEASVKDIAALN STLG |
| Post Translational Modifications | The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization. |
| Function | Membrane-bound serine protease. Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis. |
| Protein Name | Transmembrane Protease Serine 6Matriptase-2 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinThe ProcessedActivated Two-Chains Form Is Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 6 antibodyAnti-Matriptase-2 antibodyAnti-TMPRSS6 antibodyAnti-UNQ354 antibodyAnti-PRO618 antibody |
Information sourced from Uniprot.org