| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transmembrane protease serine 12 (185-235 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMPRSS12 |
| Gene ID: | 283471 |
| Uniprot ID: | TMPSC_HUMAN |
| Immunogen Region: | 185-235 aa |
| Specificity: | This antibody detects endogenous levels of TMPSC at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human TMPSC at the amino acid range 185-235 |
| Function | Required for male fertility. Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis. Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm. Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation. |
| Protein Name | Transmembrane Protease Serine 12 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosomeExpression In The Acrosome Decreases After Acrosome Reaction |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 12 antibodyAnti-TMPRSS12 antibody |
Information sourced from Uniprot.org