| Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Involved in ER homeostasis in the colonic epithelium. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tmem258Oligosaccharyl Transferase Subunit Tmem258Transmembrane Protein 258 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumCytoplasm |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tmem258 antibodyAnti-Oligosaccharyl Transferase Subunit Tmem258 antibodyAnti-Transmembrane Protein 258 antibodyAnti-TMEM258 antibodyAnti-C11orf10 antibodyAnti-HSPC005 antibody |
Information sourced from Uniprot.org
