| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMEM25 |
| Gene ID: | 84866 |
| Uniprot ID: | TMM25_HUMAN |
| Immunogen Region: | 223-322 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-322 of human TMEM25 (NP_001137506.1). |
| Immunogen Sequence: | APGPSRHPSLISSDSNNLKL NNVRLPRENMSLPSNLQLND LTPDSRAVKPADRQMAQNNS RPELLDPEPGGLLTSQGFIR LPVLGYIYRVSSVSSDEIWL |
| Tissue Specificity | Expressed throughout the brain with higher levels in the pyramidal cell layer of the hippocampal CA1 and CA3 regions. Also highly expressed within the hippocampal dentate gyrus region and cerebellum and in scattered neurons in the cerebral cortex. |
| Function | In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. |
| Protein Name | Transmembrane Protein 25 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Cell MembraneIsoform 2: SecretedIsoform 3: SecretedLate EndosomeLysosome |
| Alternative Antibody Names | Anti-Transmembrane Protein 25 antibodyAnti-TMEM25 antibodyAnti-UNQ2531 antibodyAnti-PRO6030 antibody |
Information sourced from Uniprot.org