| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transmembrane protein 108 (88-138 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM108 |
| Gene ID: |
66000 |
| Uniprot ID: |
TM108_HUMAN |
| Immunogen Region: |
88-138 aa |
| Specificity: |
This antibody detects endogenous levels of human TM108 |
| Immunogen: |
Synthesized peptide derived from the human TM108 at the amino acid range 88-138 |
| Function | Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. |
| Protein Name | Transmembrane Protein 108Retrolinkin |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinPostsynaptic DensityEndosome MembraneCell ProjectionAxonDendriteEarly Endosome |
| Alternative Antibody Names | Anti-Transmembrane Protein 108 antibodyAnti-Retrolinkin antibodyAnti-TMEM108 antibodyAnti-KIAA1690 antibodyAnti-RTLN antibodyAnti-UNQ1875 antibodyAnti-PRO4318 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
