Anti-TMEFF2 antibody (275-374) [S3MR] (STJ11103553)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TMEFF2 (275-374) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S3MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEFF2 |
| Gene ID | 23671 |
| Uniprot ID | TEFF2_HUMAN |
| Immunogen Region | 275-374 |
| Immunogen Sequence | HGKCEHSINMQEPSCRCDAG YTGQHCEKKDYSVLYVVPGP VRFQYVLIAAVIGTIQIAVI CVVVLCITRKCPRSNRIHRQ KQNTGHYSSDNTTRASTRLI |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 275-374 of human TMEFF2 (Q9UIK5). |
Additional Info
| Tissue Specificity | Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17. |
| Function | May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
| Protein Name | Tomoregulin-2Tr-2Hyperplastic Polyposis Protein 1Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains |
| Database Links | |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinIsoform 2: MembraneIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Tomoregulin-2 antibodyAnti-Tr-2 antibodyAnti-Hyperplastic Polyposis Protein 1 antibodyAnti-Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains antibodyAnti-TMEFF2 antibodyAnti-HPP1 antibodyAnti-TENB2 antibodyAnti-TPEF antibodyAnti-UNQ178 antibodyAnti-PRO204 antibody |
Information sourced from Uniprot.org