| Function | Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. May be a tumor suppressor in brain cancers. |
| Protein Name | Tomoregulin-1Tr-1H7365Transmembrane Protein With Egf-Like And One Follistatin-Like Domain |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tomoregulin-1 antibodyAnti-Tr-1 antibodyAnti-H7365 antibodyAnti-Transmembrane Protein With Egf-Like And One Follistatin-Like Domain antibodyAnti-TMEFF1 antibodyAnti-C9orf2 antibody |
Information sourced from Uniprot.org
