Anti-TMED9 antibody (1-224) (STJ116207)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TMED9 (1-224) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMED9 |
| Gene ID | 54732 |
| Uniprot ID | TMED9_HUMAN |
| Immunogen Region | 1-224 |
| Immunogen Sequence | MAVELGVLLVRPRPGTGLGR VMRTLLLVLWLATRGSALYF HIGETEKKCFIEEIPDETMV IGNYRTQLYDKQREEYQPAT PGLGMFVEVKDPEDKVILAR QYGSEGRFTFTSHTPGEHQI CLHSNSTKFSLFAGGMLRVH LDIQVGEHANDYAEIAAKDK LSELQLRVRQLVEQVEQIQK EQNYQRWREERFRQTSESTN QRVLWWSILQTLILVAIGVW QMRH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human TMED9 (NP_059980.2). |
Additional Info
| Post Translational Modifications | N-linked glycosylated containing high mannose. |
| Function | Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes.specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. |
| Protein Name | Transmembrane Emp24 Domain-Containing Protein 9Gmp25Glycoprotein 25l2P24 Family Protein Alpha-2P24alpha2P25 |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusCis-Golgi Network MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneTrans-Golgi Network MembraneCycles Between Compartments Of The Early Secretatory Pathway |
| Alternative Antibody Names | Anti-Transmembrane Emp24 Domain-Containing Protein 9 antibodyAnti-Gmp25 antibodyAnti-Glycoprotein 25l2 antibodyAnti-P24 Family Protein Alpha-2 antibodyAnti-P24alpha2 antibodyAnti-P25 antibodyAnti-TMED9 antibodyAnti-GP25L2 antibody |
Information sourced from Uniprot.org