| Function | Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally. Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions. |
| Protein Name | Transmembrane Channel-Like Protein 8Epidermodysplasia Verruciformis Protein 2 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneNucleus MembraneLocalizes To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 8 antibodyAnti-Epidermodysplasia Verruciformis Protein 2 antibodyAnti-TMC8 antibodyAnti-EVER2 antibodyAnti-EVIN2 antibody |
Information sourced from Uniprot.org
